AmiGO 2: Term Details for "T cell differentiation" (GO:0030217)

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Term Information

Accession: GO:0030217
Name: T cell differentiation
Ontology: biological_process
Synonyms: T lymphocyte differentiation, T-cell differentiation, T-lymphocyte differentiation, T cell development
Alternate IDs: GO:0042112, GO:0046652
Definition: The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. Source: GO_REF:0000022, GOC:mah, GOC:jid
Comment: Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
History: See term history for GO:0030217 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to T cell differentiation (excluding "regulates").; Link to all direct and indirect annotations to T cell differentiation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for T cell differentiation (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0032502 developmental process
GO:0048856 anatomical structure development
GO:0030154 cell differentiation
GO:0048869 cellular developmental process
GO:0009987 cellular process
GO:0048468 cell development
GO:0032501 multicellular organismal process
GO:0001775 cell activation
GO:0030097 hemopoiesis
GO:0002376 immune system process
GO:0045321 leukocyte activation
GO:0002521 leukocyte differentiation
GO:0046649 lymphocyte activation
GO:1903131 mononuclear cell differentiation
GO:0030098 lymphocyte differentiation
GO:0042110 T cell activation
GO:0030217 T cell differentiation
GO:0046632 alpha-beta T cell differentiation
GO:0045065 cytotoxic T cell differentiation
GO:0160083 exhausted T cell differentiation
GO:0033078 extrathymic T cell differentiation
GO:0042492 gamma-delta T cell differentiation
GO:0045581 negative regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
CL:0000827 pro-T cell
GO:0002572 pro-T cell differentiation
GO:0045580 regulation of T cell differentiation
GO:0045066 regulatory T cell differentiation
GO:0002568 somatic diversification of T cell receptor genes
GO:0033077 T cell differentiation in thymus
GO:0002292 T cell differentiation involved in immune response
GO:0002360 T cell lineage commitment
GO:0045058 T cell selection

Parents of T cell differentiation (GO:0030217)

subject	relation	object
T cell differentiation	RO:0002315	T cell (CL:0000084)
T cell differentiation	RO:0002162	Vertebrata (NCBITaxon:7742)
T cell differentiation	is_a	lymphocyte differentiation (GO:0030098)
T cell differentiation	is_a	T cell activation (GO:0042110)

Children of T cell differentiation (GO:0030217)

subject	relation	object
alpha-beta T cell differentiation (GO:0046632)	is_a	T cell differentiation
pro-T cell (CL:0000827)	RO:0002215	T cell differentiation
CD27-positive gamma-delta T cell (CL:0002124)	RO:0002353	T cell differentiation
mature NK T cell (CL:0000814)	RO:0002353	T cell differentiation
gamma-delta T cell differentiation (GO:0042492)	is_a	T cell differentiation
T cell differentiation in thymus (GO:0033077)	is_a	T cell differentiation
CD8-positive, alpha-beta cytokine secreting effector T cell (CL:0000908)	RO:0002353	T cell differentiation
T cell selection (GO:0045058)	BFO:0000050	T cell differentiation
cytotoxic T cell differentiation (GO:0045065)	is_a	T cell differentiation
somatic diversification of T cell receptor genes (GO:0002568)	BFO:0000050	T cell differentiation
CD27-negative gamma-delta T cell (CL:0002125)	RO:0002353	T cell differentiation
exhausted T cell differentiation (GO:0160083)	is_a	T cell differentiation
thymus (UBERON:0002370)	BFO:0000067	T cell differentiation
CD8-positive, alpha-beta cytotoxic T cell (CL:0000794)	RO:0002353	T cell differentiation
mucosal invariant T cell (CL:0000940)	RO:0002353	T cell differentiation
T cell lineage commitment (GO:0002360)	BFO:0000050	T cell differentiation
CD4-positive, alpha-beta cytotoxic T cell (CL:0000934)	RO:0002353	T cell differentiation
CD4-positive helper T cell (CL:0000492)	RO:0002353	T cell differentiation
regulatory T cell differentiation (GO:0045066)	is_a	T cell differentiation
regulation of T cell differentiation (GO:0045580)	RO:0002211	T cell differentiation
effector T cell (CL:0000911)	RO:0002353	T cell differentiation
pro-T cell differentiation (GO:0002572)	BFO:0000050	T cell differentiation
negative regulation of T cell differentiation (GO:0045581)	RO:0002212	T cell differentiation
positive regulation of T cell differentiation (GO:0045582)	RO:0002213	T cell differentiation
T cell differentiation involved in immune response (GO:0002292)	is_a	T cell differentiation
extrathymic T cell differentiation (GO:0033078)	is_a	T cell differentiation

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