AmiGO 2: Term Details for "[methionine synthase] reductase activity" (GO:0030586)

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Term Information

Accession: GO:0030586
Name: [methionine synthase] reductase activity
Ontology: molecular_function
Synonyms: [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase, methionine synthase cob(II)alamin reductase (methylating) activity, methionine synthase reductase activity, methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing), methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity
Alternate IDs: None
Definition: Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+. Source: RHEA:23908
Comment: Formerly EC:2.1.1.135.
History: See term history for GO:0030586 at QuickGO
Chem. react.: has participant hydron; has participant cob(II)alamin; has participant NADPH(4-); has participant S-adenosyl-L-methionine zwitterion; has participant methylcobalamin; has participant NADP(3-); has participant S-adenosyl-L-homocysteine zwitterion
Subset: None
Related: Link to all genes and gene products annotated to [methionine synthase] reductase activity (excluding "regulates").; Link to all direct and indirect annotations to [methionine synthase] reductase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for [methionine synthase] reductase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016722 oxidoreductase activity, acting on metal ions
GO:0016723 oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor
GO:0030586 [methionine synthase] reductase activity

Parents of [methionine synthase] reductase activity (GO:0030586)

subject	relation	object
[methionine synthase] reductase activity	RO:0000057	hydron (CHEBI:15378)
[methionine synthase] reductase activity	RO:0000057	cob(II)alamin (CHEBI:16304)
[methionine synthase] reductase activity	RO:0000057	NADPH(4-) (CHEBI:57783)
[methionine synthase] reductase activity	RO:0000057	S-adenosyl-L-methionine zwitterion (CHEBI:59789)
[methionine synthase] reductase activity	RO:0000057	methylcobalamin (CHEBI:28115)
[methionine synthase] reductase activity	RO:0000057	NADP(3-) (CHEBI:58349)
[methionine synthase] reductase activity	RO:0000057	S-adenosyl-L-homocysteine zwitterion (CHEBI:57856)
[methionine synthase] reductase activity	is_a	oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor (GO:0016723)

This term has no children.

EC: 1.16.1.8
MetaCyc: 2.1.1.135-RXN
Reactome: R-HSA-3149518
RHEA: 23908