AmiGO 2: Term Details for "beta-catenin destruction complex" (GO:0030877)

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Term Information

Accession: GO:0030877
Name: beta-catenin destruction complex
Ontology: cellular_component
Synonyms: APC-Axin-1-beta-catenin complex, Axin-APC-beta-catenin-GSK3B complex, BDC, beta-catenin degradation complex, 23S APC complex
Alternate IDs: GO:0034747, GO:0034742
Definition: A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. Source: PMID:14600025
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
History: See term history for GO:0030877 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to beta-catenin destruction complex (excluding "regulates").; Link to all direct and indirect annotations to beta-catenin destruction complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for beta-catenin destruction complex (excluding "regulates").

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GO:0005575 cellular_component
GO:0003674 molecular_function
PR:000050567 protein-containing material entity
GO:0003824 catalytic activity
GO:0032991 protein-containing complex
GO:1902494 catalytic complex
GO:0140535 intracellular protein-containing complex
GO:0030877 beta-catenin destruction complex

Parents of beta-catenin destruction complex (GO:0030877)

subject	relation	object
beta-catenin destruction complex	is_a	intracellular protein-containing complex (GO:0140535)
beta-catenin destruction complex	is_a	catalytic complex (GO:1902494)

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