Term Information

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Accession
GO:0033093
Name
Weibel-Palade body
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. Source: PMID:16087708, PMID:11935287
Comment
None
History
See term history for GO:0033093 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of Weibel-Palade body (GO:0033093)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Weibel-Palade body [is_a relation] is_a  secretory granule (GO:0030141)
Weibel-Palade body [is_a relation] is_a  clathrin-coated vesicle (GO:0030136)

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Wikipedia
Weibel-Palade_body