AmiGO 2: Term Details for "calcineurin-NFAT signaling cascade" (GO:0033173)

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Term Information

Accession: GO:0033173
Name: calcineurin-NFAT signaling cascade
Ontology: biological_process
Synonyms: calcineurin-NFAT signaling pathway, calcineurin-NFAT signalling pathway
Alternate IDs: None
Definition: Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). Source: PMID:15928679, GOC:lm, GOC:mah, PMID:12975316
Comment: None
History: See term history for GO:0033173 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to calcineurin-NFAT signaling cascade (excluding "regulates").; Link to all direct and indirect annotations to calcineurin-NFAT signaling cascade (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for calcineurin-NFAT signaling cascade (excluding "regulates").

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0019722 calcium-mediated signaling
GO:0097720 calcineurin-mediated signaling
GO:0033173 calcineurin-NFAT signaling cascade
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0070884 regulation of calcineurin-NFAT signaling cascade

Parents of calcineurin-NFAT signaling cascade (GO:0033173)

subject	relation	object
calcineurin-NFAT signaling cascade	RO:0002162	Metazoa (NCBITaxon:33208)
calcineurin-NFAT signaling cascade	is_a	calcineurin-mediated signaling (GO:0097720)

Children of calcineurin-NFAT signaling cascade (GO:0033173)

subject	relation	object
regulation of calcineurin-NFAT signaling cascade (GO:0070884)	RO:0002211	calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling cascade (GO:0070886)	RO:0002213	calcineurin-NFAT signaling cascade
negative regulation of calcineurin-NFAT signaling cascade (GO:0070885)	RO:0002212	calcineurin-NFAT signaling cascade

calcineurin-NFAT signaling cascade