AmiGO 2: Term Details for "TSC1-TSC2 complex" (GO:0033596)

Accession: GO:0033596
Name: TSC1-TSC2 complex
Ontology: cellular_component
Synonyms: tuberin-hamartin complex, tuberous sclerosis complex
Alternate IDs: None
Definition: A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. Source: PMID:9580671, PMID:17121544, PMID:10585443
Comment: None
History: See term history for GO:0033596 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to TSC1-TSC2 complex (excluding "regulates").; Link to all direct and indirect annotations to TSC1-TSC2 complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for TSC1-TSC2 complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
TSC1-TSC2 complex	is_a	protein-containing complex (GO:0032991)
TSC1-TSC2 complex	RO:0002162	cellular organisms (NCBITaxon:131567)
TSC1-TSC2 complex	BFO:0000050	cytosol (GO:0005829)

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