Term Information

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Accession
GO:0033596
Name
TSC1-TSC2 complex
Ontology
cellular_component
Synonyms
tuberin-hamartin complex, tuberous sclerosis complex
Alternate IDs
None
Definition
A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. Source: PMID:9580671, PMID:17121544, PMID:10585443
Comment
None
History
See term history for GO:0033596 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of TSC1-TSC2 complex (GO:0033596)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
TSC1-TSC2 complex [BFO:0000050 relation] BFO:0000050  cytosol (GO:0005829)
TSC1-TSC2 complex [RO:0002162 relation] RO:0002162  cellular organisms (NCBITaxon:131567)
TSC1-TSC2 complex [is_a relation] is_a  protein-containing complex (GO:0032991)

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