AmiGO 2: Term Details for "cholesterol 24-hydroxylase activity" (GO:0033781)

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Term Information

Accession: GO:0033781
Name: cholesterol 24-hydroxylase activity
Ontology: molecular_function
Synonyms: CYP46, CYP46A1, cholesterol 24-monooxygenase activity, cholesterol 24S-hydroxylase activity, cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity, cytochrome P450 46A1
Alternate IDs: None
Definition: Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+. Source: EC:1.14.14.25, RHEA:22716
Comment: None
History: See term history for GO:0033781 at QuickGO
Chem. react.: has participant FMN(3-); has participant FMNH2(2-); has participant (24S)-24-hydroxycholesterol; has participant hydron; has participant cholesterol; has participant dioxygen; has participant water
Subset: None
Related: Link to all genes and gene products annotated to cholesterol 24-hydroxylase activity (excluding "regulates").; Link to all direct and indirect annotations to cholesterol 24-hydroxylase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for cholesterol 24-hydroxylase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0004497 monooxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0033781 cholesterol 24-hydroxylase activity

Parents of cholesterol 24-hydroxylase activity (GO:0033781)

subject	relation	object
cholesterol 24-hydroxylase activity	RO:0000057	FMN(3-) (CHEBI:58210)
cholesterol 24-hydroxylase activity	RO:0000057	FMNH2(2-) (CHEBI:57618)
cholesterol 24-hydroxylase activity	RO:0000057	(24S)-24-hydroxycholesterol (CHEBI:34310)
cholesterol 24-hydroxylase activity	RO:0000057	hydron (CHEBI:15378)
cholesterol 24-hydroxylase activity	RO:0000057	cholesterol (CHEBI:16113)
cholesterol 24-hydroxylase activity	is_a	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)
cholesterol 24-hydroxylase activity	RO:0000057	dioxygen (CHEBI:15379)
cholesterol 24-hydroxylase activity	RO:0000057	water (CHEBI:15377)

This term has no children.

EC: 1.14.14.25
KEGG_REACTION: R07207
MetaCyc: 1.14.13.98-RXN
Reactome: R-HSA-192061
RHEA: 22716