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deoxyhypusine synthase activity

Term Information

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Accession
GO:0034038
Name
deoxyhypusine synthase activity
Ontology
molecular_function
Synonyms
eIF-5A-deoxyhypusine synthase activity, (4-aminobutyl)lysine synthase, spermidine dehydrogenase
Alternate IDs
None
Definition
Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+. Source: RHEA:33299, GOC:pde
Comment
Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'.
History
See term history for GO:0034038 at QuickGO
Chem. react.
has participant deoxyhypusine(2+) residue
has participant trimethylenediaminium
has participant L-lysinium residue
has participant spermidine(3+)
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0034038 from QuickGO

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Parents of deoxyhypusine synthase activity (GO:0034038)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
deoxyhypusine synthase activity [is_a relation] is_a  transferase activity, transferring alkyl or aryl (other than methyl) groups (GO:0016765)
deoxyhypusine synthase activity [RO:0000057 relation] RO:0000057  deoxyhypusine(2+) residue (CHEBI:82657)
deoxyhypusine synthase activity [RO:0000057 relation] RO:0000057  trimethylenediaminium (CHEBI:57484)
deoxyhypusine synthase activity [RO:0000057 relation] RO:0000057  L-lysinium residue (CHEBI:29969)
deoxyhypusine synthase activity [RO:0000057 relation] RO:0000057  spermidine(3+) (CHEBI:57834)

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