Term Information

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Accession
GO:0034709
Name
methylosome
Ontology
cellular_component
Synonyms
20S methylosome, 20S methyltransferase complex
Alternate IDs
None
Definition
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. Source: PMID:11713266, PMID:11756452
Comment
None
History
See term history for GO:0034709 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0034709 from QuickGO

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Parents of methylosome (GO:0034709)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
methylosome [is_a relation] is_a  methyltransferase complex (GO:0034708)
methylosome [BFO:0000050 relation] BFO:0000050  cytoplasm (GO:0005737)

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None.