Term Information

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Accession
GO:0035242
Name
protein-arginine omega-N asymmetric methyltransferase activity
Ontology
molecular_function
Synonyms
protein arginine omega-N asymmetric methylase activity, protein arginine omega-N asymmetric methyltransferase activity, S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming), type I PRMT activity, type I protein arginine methyltransferase activity
Alternate IDs
None
Definition
Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. Source: PMID:14705965
Comment
Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'.
History
See term history for GO:0035242 at QuickGO
Chem. react.
has participant S-adenosyl-L-homocysteine zwitterion
has participant L-argininium residue
has participant hydron
has participant S-adenosyl-L-methionine zwitterion
has participant N(omega),N(omega)-dimethyl-L-arginine(1+) residue
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0035242 from QuickGO

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Parents of protein-arginine omega-N asymmetric methyltransferase activity (GO:0035242)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
protein-arginine omega-N asymmetric methyltransferase activity [RO:0000057 relation] RO:0000057  S-adenosyl-L-homocysteine zwitterion (CHEBI:57856)
protein-arginine omega-N asymmetric methyltransferase activity [RO:0000057 relation] RO:0000057  L-argininium residue (CHEBI:29965)
protein-arginine omega-N asymmetric methyltransferase activity [RO:0000057 relation] RO:0000057  hydron (CHEBI:15378)
protein-arginine omega-N asymmetric methyltransferase activity [RO:0000057 relation] RO:0000057  S-adenosyl-L-methionine zwitterion (CHEBI:59789)
protein-arginine omega-N asymmetric methyltransferase activity [is_a relation] is_a  protein-arginine N-methyltransferase activity (GO:0016274)
protein-arginine omega-N asymmetric methyltransferase activity [RO:0000057 relation] RO:0000057  N(omega),N(omega)-dimethyl-L-arginine(1+) residue (CHEBI:61897)

This term has no children.

EC
2.1.1.319
Reactome
R-HSA-9729283
RHEA
48096