AmiGO 2: Term Details for "protein-arginine omega-N symmetric methyltransferase activity" (GO:0035243)

Term Information

Accession: GO:0035243
Name: protein-arginine omega-N symmetric methyltransferase activity
Ontology: molecular_function
Synonyms: protein arginine omega-N symmetric methylase activity, protein arginine omega-N symmetric methyltransferase activity, S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming), type II PRMT activity, type II protein arginine methyltransferase activity
Alternate IDs: None
Definition: Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues. Source: EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069
Comment: Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'.
History: See term history for GO:0035243 at QuickGO
Chem. react.: has participant L-argininium residue; has participant S-adenosyl-L-methionine zwitterion; has participant S-adenosyl-L-homocysteine zwitterion; has participant N(omega),N('omega)-dimethyl-L-arginine(1+) residue; has participant hydron
Subset: None
Related: Link to all genes and gene products annotated to protein-arginine omega-N symmetric methyltransferase activity (excluding "regulates").; Link to all direct and indirect annotations to protein-arginine omega-N symmetric methyltransferase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for protein-arginine omega-N symmetric methyltransferase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0016740 transferase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
GO:0140096 catalytic activity, acting on a protein
GO:0008170 N-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016273 arginine N-methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity

Parents of protein-arginine omega-N symmetric methyltransferase activity (GO:0035243)

subject	relation	object
protein-arginine omega-N symmetric methyltransferase activity	is_a	protein-arginine N-methyltransferase activity (GO:0016274)
protein-arginine omega-N symmetric methyltransferase activity	RO:0000057	L-argininium residue (CHEBI:29965)
protein-arginine omega-N symmetric methyltransferase activity	RO:0000057	S-adenosyl-L-methionine zwitterion (CHEBI:59789)
protein-arginine omega-N symmetric methyltransferase activity	RO:0000057	S-adenosyl-L-homocysteine zwitterion (CHEBI:57856)
protein-arginine omega-N symmetric methyltransferase activity	RO:0000057	N(omega),N('omega)-dimethyl-L-arginine(1+) residue (CHEBI:88221)
protein-arginine omega-N symmetric methyltransferase activity	RO:0000057	hydron (CHEBI:15378)

This term has no children.

EC: 2.1.1.320
Reactome: R-HSA-6804383
RESID: AA0067; AA0069
RHEA: 48108