AmiGO 2: Term Details for "hippo signaling" (GO:0035329)

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Term Information

Accession: GO:0035329
Name: hippo signaling
Ontology: biological_process
Synonyms: hippo signal transduction, hippo signaling pathway, hippo signaling cascade, hippo signalling cascade, SWH pathway, Salvador-Warts-Hippo signaling pathway
Alternate IDs: None
Definition: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation. Source: PMID:17318211, PMID:18328423, PMID:36347846
Comment: None
History: See term history for GO:0035329 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to hippo signaling (excluding "regulates").; Link to all direct and indirect annotations to hippo signaling (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for hippo signaling (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical structure
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0035329 hippo signaling
GO:0035331 negative regulation of hippo signaling
GO:1990957 NPHP complex
GO:0035332 positive regulation of hippo signaling
GO:0035330 regulation of hippo signaling

Parents of hippo signaling (GO:0035329)

subject	relation	object
hippo signaling	is_a	intracellular signal transduction (GO:0035556)

Children of hippo signaling (GO:0035329)

subject	relation	object
regulation of hippo signaling (GO:0035330)	RO:0002211	hippo signaling
NPHP complex (GO:1990957)	RO:0002216	hippo signaling
positive regulation of hippo signaling (GO:0035332)	RO:0002213	hippo signaling
negative regulation of hippo signaling (GO:0035331)	RO:0002212	hippo signaling

Reactome: R-HSA-2028269