AmiGO 2: Term Details for "Notch receptor processing, ligand-dependent" (GO:0035333)

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Term Information

Accession: GO:0035333
Name: Notch receptor processing, ligand-dependent
Ontology: biological_process
Synonyms: Notch S2 cleavage, Notch S3 cleavage
Alternate IDs: None
Definition: The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). Source: PMID:12651094, GOC:bf
Comment: None
History: See term history for GO:0035333 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to Notch receptor processing, ligand-dependent (excluding "regulates").; Link to all direct and indirect annotations to Notch receptor processing, ligand-dependent (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for Notch receptor processing, ligand-dependent (excluding "regulates").

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0071704 organic substance metabolic process
GO:0019538 protein metabolic process
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0043170 macromolecule metabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:0006508 proteolysis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0033619 membrane protein proteolysis
GO:0031293 membrane protein intracellular domain proteolysis
GO:0007220 Notch receptor processing
GO:0007219 Notch signaling pathway
GO:0035333 Notch receptor processing, ligand-dependent

Parents of Notch receptor processing, ligand-dependent (GO:0035333)

subject	relation	object
Notch receptor processing, ligand-dependent	BFO:0000050	Notch receptor processing (GO:0007220)
Notch receptor processing, ligand-dependent	is_a	membrane protein intracellular domain proteolysis (GO:0031293)
Notch receptor processing, ligand-dependent	BFO:0000050	Notch signaling pathway (GO:0007219)

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