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broad specificity oxidative DNA demethylase activity

Term Information

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Accession
GO:0035516
Name
broad specificity oxidative DNA demethylase activity
Ontology
molecular_function
Synonyms
2-oxoglutarate-dependent DNA demethylase, 1-ethyladenine demethylase activity, 5-formylcytosine dioxygenase activity, 5-hydroxymethylcytosine dioxygenase activity, 5fC dioxygenase, 5hmC dioxygenase, N1-methyladenine demethylase activity, N3-methylcytosine demethylase activity, oxidative DNA demethylase activity
Alternate IDs
GO:0103053, GO:0103051, GO:0103052
Definition
Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA. Source: RHEA:30299, PMID:12594517, PMID:16482161, PMID:18775698, PMID:19786499
Comment
This reaction directly reverses the alkylation on a nucleotide within DNA. Do not confuse with 5-methylcytosine dioxygenase activity ; GO:0070579, which removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system.
History
See term history for GO:0035516 at QuickGO
Chem. react.
has participant H group
has participant methyl group
has participant succinate(2-)
has participant 2-oxoglutarate(2-)
has participant dioxygen
has participant carbon dioxide
has participant formaldehyde
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of broad specificity oxidative DNA demethylase activity (GO:0035516)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
broad specificity oxidative DNA demethylase activity [RO:0000057 relation] RO:0000057  H group (CHEBI:64428)
broad specificity oxidative DNA demethylase activity [RO:0000057 relation] RO:0000057  methyl group (CHEBI:32875)
broad specificity oxidative DNA demethylase activity [RO:0000057 relation] RO:0000057  succinate(2-) (CHEBI:30031)
broad specificity oxidative DNA demethylase activity [is_a relation] is_a  2-oxoglutarate-dependent dioxygenase activity (GO:0016706)
broad specificity oxidative DNA demethylase activity [is_a relation] is_a  DNA demethylase activity (GO:0035514)
broad specificity oxidative DNA demethylase activity [RO:0000057 relation] RO:0000057  2-oxoglutarate(2-) (CHEBI:16810)
broad specificity oxidative DNA demethylase activity [RO:0000057 relation] RO:0000057  dioxygen (CHEBI:15379)
broad specificity oxidative DNA demethylase activity [RO:0000057 relation] RO:0000057  carbon dioxide (CHEBI:16526)
broad specificity oxidative DNA demethylase activity [RO:0000057 relation] RO:0000057  formaldehyde (CHEBI:16842)

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