AmiGO 2: Term Details for "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity" (GO:0035539)

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Term Information

Accession: GO:0035539
Name: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
Ontology: molecular_function
Synonyms: 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity, 8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity, 8-oxo-dGTP pyrophosphohydrolase activity, 8-oxo-dGTPase activity
Alternate IDs: None
Definition: Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. Source: PMID:7782328, RHEA:31575, PMID:7859359, PMID:17804481
Comment: None
History: See term history for GO:0035539 at QuickGO
Chem. react.: has participant hydron; has participant 8-oxo-dGMP(2-); has participant water; has participant diphosphate(3-); has participant 8-oxo-dGTP(4-)
Subset: None
Related: Link to all genes and gene products annotated to 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity (excluding "regulates").; Link to all direct and indirect annotations to 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity (excluding "regulates").

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OLSVis (interactive)

Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016462 pyrophosphatase activity
GO:0047429 nucleoside triphosphate diphosphatase activity
GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

Parents of 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity (GO:0035539)

subject	relation	object
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	RO:0000057	hydron (CHEBI:15378)
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	RO:0000057	8-oxo-dGMP(2-) (CHEBI:63224)
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	RO:0000057	water (CHEBI:15377)
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	RO:0000057	diphosphate(3-) (CHEBI:33019)
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	is_a	nucleoside triphosphate diphosphatase activity (GO:0047429)
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	RO:0000057	8-oxo-dGTP(4-) (CHEBI:77896)

This term has no children.

EC: 3.6.1.55
Reactome: R-HSA-2395869; R-HSA-2395849; R-HSA-9750555
RHEA: 31575