AmiGO 2: Term Details for "MKS complex" (GO:0036038)

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Term Information

Accession: GO:0036038
Name: MKS complex
Ontology: cellular_component
Synonyms: MKS module, B9 complex, tectonic complex, tectonic-like complex, TCTN-B9D complex
Alternate IDs: None
Definition: A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane. Source: GOC:sp, PMID:21422230, GOC:cilia, PMID:21725307, PMID:26595381, PMID:21565611, PMID:22179047, PMID:26982032, PMID:25869670
Comment: Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.
History: See term history for GO:0036038 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to MKS complex (excluding "regulates").; Link to all direct and indirect annotations to MKS complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for MKS complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
GO:0008150 biological_process
CARO:0000000 anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
UBERON:0001062 anatomical entity
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0071840 cellular component organization or biogenesis
CARO:0000006 material anatomical entity
GO:0042995 cell projection
GO:0044085 cellular component biogenesis
GO:0016043 cellular component organization
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0043226 organelle
GO:0022607 cellular component assembly
GO:0005575 cellular_component
GO:0043227 membrane-bounded organelle
GO:0120025 plasma membrane bounded cell projection
GO:0043933 protein-containing complex organization
PR:000050567 protein-containing material entity
GO:0005929 cilium
GO:0065003 protein-containing complex assembly
GO:0035869 ciliary transition zone
GO:0032991 protein-containing complex
GO:1905350 Y-shaped link assembly
GO:0036038 MKS complex

Parents of MKS complex (GO:0036038)

subject	relation	object
MKS complex	RO:0002162	Eukaryota (NCBITaxon:2759)
MKS complex	BFO:0000050	ciliary transition zone (GO:0035869)
MKS complex	is_a	protein-containing complex (GO:0032991)
MKS complex	RO:0002216	Y-shaped link assembly (GO:1905350)

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