AmiGO 2: Term Details for "calcitriol biosynthetic process from calciol" (GO:0036378)

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Term Information

Accession: GO:0036378
Name: calcitriol biosynthetic process from calciol
Ontology: biological_process
Synonyms: calcitriol biosynthesis from calciol, vitamin D3 activation, 1alpha,25(OH)2D3 biosynthesis, 1alpha,25-dihydroxycholecalciferol biosynthesis, 1alpha,25-dihydroxyvitamin D3 biosynthesis
Alternate IDs: None
Definition: Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol. Source: GOC:BHF, PMID:17426122, PMID:20511049, GOC:rl
Comment: None
History: See term history for GO:0036378 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to calcitriol biosynthetic process from calciol (excluding "regulates").; Link to all direct and indirect annotations to calcitriol biosynthetic process from calciol (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for calcitriol biosynthetic process from calciol (excluding "regulates").

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0071704 organic substance metabolic process
GO:0044238 primary metabolic process
GO:0044281 small molecule metabolic process
GO:0044249 cellular biosynthetic process
GO:0006629 lipid metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:1901615 organic hydroxy compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0044283 small molecule biosynthetic process
GO:0006766 vitamin metabolic process
GO:0006066 alcohol metabolic process
GO:0006775 fat-soluble vitamin metabolic process
GO:0008610 lipid biosynthetic process
GO:1901362 organic cyclic compound biosynthetic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:0008202 steroid metabolic process
GO:0009110 vitamin biosynthetic process
GO:0046165 alcohol biosynthetic process
GO:0042362 fat-soluble vitamin biosynthetic process
GO:0019751 polyol metabolic process
GO:1902652 secondary alcohol metabolic process
GO:0006694 steroid biosynthetic process
GO:0042359 vitamin D metabolic process
GO:0046173 polyol biosynthetic process
GO:0042368 vitamin D biosynthetic process
GO:0070640 vitamin D3 metabolic process
GO:0036378 calcitriol biosynthetic process from calciol
GO:0004498 calcidiol 1-monooxygenase activity
GO:0030343 vitamin D3 25-hydroxylase activity

Parents of calcitriol biosynthetic process from calciol (GO:0036378)

subject	relation	object
calcitriol biosynthetic process from calciol	is_a	vitamin D biosynthetic process (GO:0042368)
calcitriol biosynthetic process from calciol	RO:0004008	calcitriol (CHEBI:17823)
calcitriol biosynthetic process from calciol	is_a	vitamin D3 metabolic process (GO:0070640)
calcitriol biosynthetic process from calciol	is_a	polyol biosynthetic process (GO:0046173)
calcitriol biosynthetic process from calciol	RO:0004009	calciol (CHEBI:28940)

Children of calcitriol biosynthetic process from calciol (GO:0036378)

subject	relation	object
vitamin D3 25-hydroxylase activity (GO:0030343)	BFO:0000050	calcitriol biosynthetic process from calciol
calcidiol 1-monooxygenase activity (GO:0004498)	BFO:0000050	calcitriol biosynthetic process from calciol

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