AmiGO 2: Term Details for "IRE1-mediated unfolded protein response" (GO:0036498)

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Term Information

Accession: GO:0036498
Name: IRE1-mediated unfolded protein response
Ontology: biological_process
Synonyms: IRE1 branch of UPR, UPR signaling by IRE1 stress sensor, endoplasmic reticulum unfolded protein response; IRE1 signaling, ERN1-mediated unfolded protein response, IRE1 signaling in response to endoplasmic reticulum stress, inositol-requiring enzyme 1-mediated unfolded protein response, inositol-requiring transmembrane kinase/endonuclease signal transduction, IRE1alpha unfolded protein response, IRE1p unfolded protein response, IRE1 signal transduction pathway
Alternate IDs: None
Definition: The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. Source: GOC:PARL, PMID:22013210, GOC:bf
Comment: Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
History: See term history for GO:0036498 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to IRE1-mediated unfolded protein response (excluding "regulates").; Link to all direct and indirect annotations to IRE1-mediated unfolded protein response (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for IRE1-mediated unfolded protein response (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0006950 response to stress
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical structure
GO:0051716 cellular response to stimulus
GO:0033554 cellular response to stress
GO:0050794 regulation of cellular process
GO:0035966 response to topologically incorrect protein
GO:0023052 signaling
GO:0035967 cellular response to topologically incorrect protein
GO:0005622 intracellular anatomical structure
GO:0006986 response to unfolded protein
GO:0007165 signal transduction
GO:0034620 cellular response to unfolded protein
GO:0035556 intracellular signal transduction
GO:0034976 response to endoplasmic reticulum stress
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0036498 IRE1-mediated unfolded protein response
GO:1990332 Ire1 complex
GO:1903895 negative regulation of IRE1-mediated unfolded protein response
GO:1903896 positive regulation of IRE1-mediated unfolded protein response
GO:1903894 regulation of IRE1-mediated unfolded protein response

Parents of IRE1-mediated unfolded protein response (GO:0036498)

subject	relation	object
IRE1-mediated unfolded protein response	is_a	endoplasmic reticulum unfolded protein response (GO:0030968)

Children of IRE1-mediated unfolded protein response (GO:0036498)

subject	relation	object
positive regulation of IRE1-mediated unfolded protein response (GO:1903896)	RO:0002213	IRE1-mediated unfolded protein response
negative regulation of IRE1-mediated unfolded protein response (GO:1903895)	RO:0002212	IRE1-mediated unfolded protein response
regulation of IRE1-mediated unfolded protein response (GO:1903894)	RO:0002211	IRE1-mediated unfolded protein response
Ire1 complex (GO:1990332)	RO:0002216	IRE1-mediated unfolded protein response

Reactome: R-HSA-381070