AmiGO 2: Term Details for "p38MAPK cascade" (GO:0038066)

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Term Information

Accession: GO:0038066
Name: p38MAPK cascade
Ontology: biological_process
Synonyms: p38 MAPK cascade, p38 cascade, MAPK14 cascade, osmosensory signaling MAPK cascade
Alternate IDs: None
Definition: A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. Source: PMID:20811974, PMID:23125017, PMID:32794416
Comment: None
History: See term history for GO:0038066 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to p38MAPK cascade (excluding "regulates").; Link to all direct and indirect annotations to p38MAPK cascade (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for p38MAPK cascade (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0000165 MAPK cascade
GO:0038066 p38MAPK cascade
GO:1903753 negative regulation of p38MAPK cascade
GO:1900745 positive regulation of p38MAPK cascade
GO:1900744 regulation of p38MAPK cascade

Parents of p38MAPK cascade (GO:0038066)

subject	relation	object
p38MAPK cascade	is_a	MAPK cascade (GO:0000165)

Children of p38MAPK cascade (GO:0038066)

subject	relation	object
regulation of p38MAPK cascade (GO:1900744)	RO:0002211	p38MAPK cascade
positive regulation of p38MAPK cascade (GO:1900745)	RO:0002213	p38MAPK cascade
negative regulation of p38MAPK cascade (GO:1903753)	RO:0002212	p38MAPK cascade

p38MAPK cascade