AmiGO 2: Term Details for "ERBB2 signaling pathway" (GO:0038128)

Accession: GO:0038128
Name: ERBB2 signaling pathway
Ontology: biological_process
Synonyms: ERBB2 signalling pathway, HER2 signaling pathway, NEU signaling, receptor tyrosine-protein kinase erbB-2 signaling pathway
Alternate IDs: None
Definition: The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. Source: Reactome:R-HSA-1227986, PMID:16460914, GOC:jc
Comment: None
History: See term history for GO:0038128 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to ERBB2 signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to ERBB2 signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for ERBB2 signaling pathway (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
ERBB2 signaling pathway	is_a	ERBB signaling pathway (GO:0038127)

subject	relation	object
ERBB2-ERBB3 signaling pathway (GO:0038133)	is_a	ERBB2 signaling pathway
ERBB2-EGFR signaling pathway (GO:0038134)	is_a	ERBB2 signaling pathway
ERBB2-ERBB4 signaling pathway (GO:0038135)	is_a	ERBB2 signaling pathway

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