AmiGO 2: Term Details for "ERBB2-ERBB3 signaling pathway" (GO:0038133)

Accession: GO:0038133
Name: ERBB2-ERBB3 signaling pathway
Ontology: biological_process
Synonyms: ERBB2-ERBB3 signalling pathway, HER2-HER3 signaling pathway
Alternate IDs: None
Definition: The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission. Source: GOC:signaling, Reactome:R-HSA-1963589, PMID:16460914
Comment: None
History: See term history for GO:0038133 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to ERBB2-ERBB3 signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to ERBB2-ERBB3 signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for ERBB2-ERBB3 signaling pathway (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
ERBB2-ERBB3 signaling pathway	is_a	ERBB3 signaling pathway (GO:0038129)
ERBB2-ERBB3 signaling pathway	is_a	ERBB2 signaling pathway (GO:0038128)

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