AmiGO 2: Term Details for "MDA-5 signaling pathway" (GO:0039530)

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Term Information

Accession: GO:0039530
Name: MDA-5 signaling pathway
Ontology: biological_process
Synonyms: IFIH1 signaling pathway, MDA-5 signalling pathway, melanoma differentiation-associated gene 5 signaling pathway, MDA5 signaling pathway
Alternate IDs: None
Definition: The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines. Source: PMID:33087405, PMID:19620789, GOC:bf
Comment: None
History: See term history for GO:0039530 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to MDA-5 signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to MDA-5 signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for MDA-5 signaling pathway (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009607 response to biotic stimulus
GO:0009605 response to external stimulus
GO:0044419 biological process involved in interspecies interaction between organisms
GO:0043207 response to external biotic stimulus
GO:0006952 defense response
GO:0050789 regulation of biological process
GO:0048583 regulation of response to stimulus
GO:0051707 response to other organism
GO:0050896 response to stimulus
GO:0006950 response to stress
GO:0098542 defense response to other organism
GO:0002376 immune system process
GO:0048518 positive regulation of biological process
GO:0002682 regulation of immune system process
GO:0080134 regulation of response to stress
GO:0140546 defense response to symbiont
GO:0006955 immune response
GO:0045087 innate immune response
GO:0002684 positive regulation of immune system process
GO:0048584 positive regulation of response to stimulus
GO:0031347 regulation of defense response
GO:0050776 regulation of immune response
GO:0002831 regulation of response to biotic stimulus
GO:0032101 regulation of response to external stimulus
GO:0065007 biological regulation
GO:0031349 positive regulation of defense response
GO:0050778 positive regulation of immune response
GO:0002833 positive regulation of response to biotic stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0045088 regulation of innate immune response
GO:0007165 signal transduction
GO:0002253 activation of immune response
GO:0009987 cellular process
GO:0002764 immune response-regulating signaling pathway
GO:0045089 positive regulation of innate immune response
GO:0002218 activation of innate immune response
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0002757 immune response-activating signaling pathway
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0002758 innate immune response-activating signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0002221 pattern recognition receptor signaling pathway
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
GO:0039530 MDA-5 signaling pathway
GO:0039534 negative regulation of MDA-5 signaling pathway
GO:1900245 positive regulation of MDA-5 signaling pathway
GO:0039533 regulation of MDA-5 signaling pathway

Parents of MDA-5 signaling pathway (GO:0039530)

subject	relation	object
MDA-5 signaling pathway	is_a	cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)

Children of MDA-5 signaling pathway (GO:0039530)

subject	relation	object
negative regulation of MDA-5 signaling pathway (GO:0039534)	RO:0002212	MDA-5 signaling pathway
positive regulation of MDA-5 signaling pathway (GO:1900245)	RO:0002213	MDA-5 signaling pathway
regulation of MDA-5 signaling pathway (GO:0039533)	RO:0002211	MDA-5 signaling pathway

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