AmiGO 2: Term Details for "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity" (GO:0039548)

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Term Information

Accession: GO:0039548
Name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Ontology: biological_process
Synonyms: inhibition of IRF3-dependent antiviral response, inhibition of host IRF3 by virus, suppression by virus of host IRF3 activity, suppression by virus of host interferon regulatory factor 3, suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Alternate IDs: None
Definition: A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. Source: PMID:21632562
Comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.
History: See term history for GO:0039548 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity (excluding "regulates").; Link to all direct and indirect annotations to symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity (excluding "regulates").

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GO:0008150 biological_process
GO:0050896 response to stimulus
GO:0009607 response to biotic stimulus
GO:0009605 response to external stimulus
GO:0044419 biological process involved in interspecies interaction between organisms
GO:0043207 response to external biotic stimulus
GO:0051701 biological process involved in interaction with host
GO:0044403 biological process involved in symbiotic interaction
GO:0051707 response to other organism
GO:0044003 modulation by symbiont of host process
GO:0035821 modulation of process of another organism
GO:0052173 response to defenses of other organism
GO:0075136 response to host
GO:0052200 response to host defenses
GO:0009987 cellular process
GO:0052572 response to host immune response
GO:0052031 symbiont-mediated perturbation of host defense response
GO:0044068 symbiont-mediated perturbation of host cellular process
GO:0030682 symbiont-mediated perturbation of host defenses
GO:0052553 symbiont-mediated perturbation of host immune response
GO:0052167 symbiont-mediated perturbation of host innate immune response
GO:0052027 symbiont-mediated perturbation of host signal transduction pathway
GO:0044414 symbiont-mediated suppression of host defenses
GO:0052562 symbiont-mediated suppression of host immune response
GO:0052170 symbiont-mediated suppression of host innate immune response
GO:0052029 symbiont-mediated suppression of host signal transduction pathway
GO:0052078 symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway
GO:0039537 symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway
GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity

Parents of symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity (GO:0039548)

subject	relation	object
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity	is_a	symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway (GO:0039537)

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VZ: 757