obsolete suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation
Ontology
biological_process
Synonyms
inhibition of phosphorylation-induced activation of host IRF3, inhibition of virus-induced IRF-3 phosphorylation
Alternate IDs
None
Definition
OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes.
Source:PMID:12829834,
PMID:20631144,
PMID:11124948,
PMID:9566918
Comment
The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
Link
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Link
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