Term Information

Feedback 
Accession
GO:0039557
Name
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
Ontology
biological_process
Synonyms
inhibition of host IRF7 by virus, inhibition of host interferon regulatory factor-7 by virus, suppression by virus of host IRF7 activity, suppression by virus of host interferon regulatory factor 7 activity, suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
Alternate IDs
None
Definition
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. Source: PMID:16014964, PMID:11943871, PMID:19557165
Comment
This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.
History
See term history for GO:0039557 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

Loading...
pending...
View this term in QuickGO.

Graph of GO:0039557 from QuickGO

Additional external viewing options
Additional internal viewing options
Parents of symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity (GO:0039557)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity [is_a relation] is_a  symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway (GO:0039537)

This term has no children.

VZ
653