obsolete regulation of molecular function, epigenetic
Ontology
biological_process
Synonyms
regulation of protein activity, epigenetic
Alternate IDs
None
Definition
OBSOLETE. Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
Source:
GOC:dph,
GOC:tb,
GOC:ems,
PMID:11050225,
PMID:11685242,
PMID:11447696,
PMID:10611975,
PMID:11782551
Comment
This term was obsoleted because it is not an active process.
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