AmiGO 2: Term Details for "macrophage activation" (GO:0042116)

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Term Information

Accession: GO:0042116
Name: macrophage activation
Ontology: biological_process
Synonyms: macrophage polarization
Alternate IDs: None
Definition: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. Source: GOC:mgi_curators, PMID:14506301, ISBN:0781735149
Comment: None
History: See term history for GO:0042116 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to macrophage activation (excluding "regulates").; Link to all direct and indirect annotations to macrophage activation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for macrophage activation (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0032501 multicellular organismal process
GO:0001775 cell activation
GO:0002376 immune system process
GO:0045321 leukocyte activation
GO:0002274 myeloid leukocyte activation
GO:0042116 macrophage activation
GO:0002281 macrophage activation involved in immune response
GO:0001774 microglial cell activation
GO:0043031 negative regulation of macrophage activation
GO:0043032 positive regulation of macrophage activation
GO:0043030 regulation of macrophage activation

Parents of macrophage activation (GO:0042116)

subject	relation	object
macrophage activation	RO:0004009	macrophage (CL:0000235)
macrophage activation	is_a	myeloid leukocyte activation (GO:0002274)

Children of macrophage activation (GO:0042116)

subject	relation	object
positive regulation of macrophage activation (GO:0043032)	RO:0002213	macrophage activation
negative regulation of macrophage activation (GO:0043031)	RO:0002212	macrophage activation
macrophage activation involved in immune response (GO:0002281)	is_a	macrophage activation
microglial cell activation (GO:0001774)	is_a	macrophage activation
regulation of macrophage activation (GO:0043030)	RO:0002211	macrophage activation

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