AmiGO 2: Term Details for "MHC class I peptide loading complex" (GO:0042824)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0042824
Name: MHC class I peptide loading complex
Ontology: cellular_component
Synonyms: peptide-loading complex, PLC
Alternate IDs: None
Definition: A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. Source: GOC:jl, PMID:10631934
Comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
History: See term history for GO:0042824 at QuickGO
Chem. react.: None
Subset: goslim_pir
Related: Link to all genes and gene products annotated to MHC class I peptide loading complex (excluding "regulates").; Link to all direct and indirect annotations to MHC class I peptide loading complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for MHC class I peptide loading complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

CARO:0030000 biological entity
GO:0008150 biological_process
CARO:0000000 anatomical entity
GO:0009987 cellular process
UBERON:0001062 anatomical entity
GO:0071840 cellular component organization or biogenesis
CARO:0000006 material anatomical entity
UBERON:0000061 anatomical structure
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0044085 cellular component biogenesis
GO:0016043 cellular component organization
CARO:0000003 connected anatomical structure
GO:0002376 immune system process
GO:0005622 intracellular anatomical structure
UBERON:0000465 material anatomical entity
GO:0043226 organelle
GO:0019882 antigen processing and presentation
GO:0022607 cellular component assembly
GO:0005575 cellular_component
GO:0043229 intracellular organelle
GO:0043227 membrane-bounded organelle
GO:0065003 protein-containing complex assembly
GO:0043933 protein-containing complex organization
GO:0048002 antigen processing and presentation of peptide antigen
GO:0005737 cytoplasm
GO:0012505 endomembrane system
GO:0005783 endoplasmic reticulum
GO:0043231 intracellular membrane-bounded organelle
GO:0016020 membrane
GO:0002396 MHC protein complex assembly
GO:0031984 organelle subcompartment
PR:000050567 protein-containing material entity
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0098827 endoplasmic reticulum subcompartment
GO:0002397 MHC class I protein complex assembly
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network
GO:0031090 organelle membrane
GO:0002501 peptide antigen assembly with MHC protein complex
GO:0032991 protein-containing complex
GO:0005789 endoplasmic reticulum membrane
GO:0140534 endoplasmic reticulum protein-containing complex
GO:0098796 membrane protein complex
GO:0002502 peptide antigen assembly with MHC class I protein complex
GO:0042824 MHC class I peptide loading complex
GO:0042825 TAP complex
GO:0061779 Tapasin-ERp57 complex

Parents of MHC class I peptide loading complex (GO:0042824)

subject	relation	object
MHC class I peptide loading complex	RO:0002216	peptide antigen assembly with MHC class I protein complex (GO:0002502)
MHC class I peptide loading complex	is_a	endoplasmic reticulum protein-containing complex (GO:0140534)
MHC class I peptide loading complex	BFO:0000050	endoplasmic reticulum membrane (GO:0005789)
MHC class I peptide loading complex	is_a	membrane protein complex (GO:0098796)

Children of MHC class I peptide loading complex (GO:0042824)

subject	relation	object
Tapasin-ERp57 complex (GO:0061779)	BFO:0000050	MHC class I peptide loading complex
TAP complex (GO:0042825)	BFO:0000050	MHC class I peptide loading complex

MHC class I peptide loading complex