AmiGO 2: Term Details for "interleukin-12 complex" (GO:0043514)

Accession: GO:0043514
Name: interleukin-12 complex
Ontology: cellular_component
Synonyms: IL-12 complex, IL12A, IL12B, p35, p40
Alternate IDs: None
Definition: A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space. Source: PMID:12948519, GOC:add, GOC:mah, GOC:ebc, PMID:1381512
Comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
History: See term history for GO:0043514 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to interleukin-12 complex (excluding "regulates").; Link to all direct and indirect annotations to interleukin-12 complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for interleukin-12 complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
interleukin-12 complex	is_a	protein-containing complex (GO:0032991)
interleukin-12 complex	BFO:0000050	extracellular space (GO:0005615)

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