AmiGO 2: Term Details for "PCNA complex" (GO:0043626)

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Term Information

Accession: GO:0043626
Name: PCNA complex
Ontology: cellular_component
Synonyms: PCNA homotrimer, proliferating cell nuclear antigen complex, sliding clamp
Alternate IDs: None
Definition: A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. Source: PMID:12829735, GOC:jl
Comment: None
History: See term history for GO:0043626 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to PCNA complex (excluding "regulates").; Link to all direct and indirect annotations to PCNA complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for PCNA complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0005575 cellular_component
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0003674 molecular_function
GO:0005622 intracellular anatomical structure
GO:0098772 molecular function regulator activity
GO:0043226 organelle
GO:0030234 enzyme regulator activity
GO:0043229 intracellular organelle
GO:0043227 membrane-bounded organelle
GO:0140677 molecular function activator activity
GO:0008047 enzyme activator activity
GO:0043231 intracellular membrane-bounded organelle
GO:0032991 protein-containing complex
PR:000050567 protein-containing material entity
GO:0030337 DNA polymerase processivity factor activity
GO:0150005 enzyme activator complex
GO:0005634 nucleus
GO:0044796 DNA polymerase processivity factor complex
GO:0140513 nuclear protein-containing complex
GO:0043626 PCNA complex

Parents of PCNA complex (GO:0043626)

subject	relation	object
PCNA complex	is_a	nuclear protein-containing complex (GO:0140513)
PCNA complex	is_a	DNA polymerase processivity factor complex (GO:0044796)

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