AmiGO 2: Term Details for "T-helper 2 cell differentiation" (GO:0045064)

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Term Information

Accession: GO:0045064
Name: T-helper 2 cell differentiation
Ontology: biological_process
Synonyms: T-helper 2 cell development
Alternate IDs: None
Definition: The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4. Source: GOC:ebc, CL:0000546
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
History: See term history for GO:0045064 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to T-helper 2 cell differentiation (excluding "regulates").; Link to all direct and indirect annotations to T-helper 2 cell differentiation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for T-helper 2 cell differentiation (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0032502 developmental process
GO:0048856 anatomical structure development
GO:0030154 cell differentiation
GO:0048869 cellular developmental process
GO:0009987 cellular process
GO:0048468 cell development
GO:0002376 immune system process
GO:0032501 multicellular organismal process
GO:0001775 cell activation
GO:0030097 hemopoiesis
GO:0002252 immune effector process
GO:0006955 immune response
GO:0002263 cell activation involved in immune response
GO:0045321 leukocyte activation
GO:0002521 leukocyte differentiation
GO:0002366 leukocyte activation involved in immune response
GO:0046649 lymphocyte activation
GO:1903131 mononuclear cell differentiation
GO:0002285 lymphocyte activation involved in immune response
GO:0030098 lymphocyte differentiation
GO:0042110 T cell activation
GO:0046631 alpha-beta T cell activation
GO:0002286 T cell activation involved in immune response
GO:0030217 T cell differentiation
GO:0002287 alpha-beta T cell activation involved in immune response
GO:0046632 alpha-beta T cell differentiation
GO:0035710 CD4-positive, alpha-beta T cell activation
GO:0002292 T cell differentiation involved in immune response
GO:0002293 alpha-beta T cell differentiation involved in immune response
GO:0043367 CD4-positive, alpha-beta T cell differentiation
GO:0050896 response to stimulus
GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response
GO:0042093 T-helper cell differentiation
GO:0042092 type 2 immune response
GO:0045064 T-helper 2 cell differentiation
GO:0045629 negative regulation of T-helper 2 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045628 regulation of T-helper 2 cell differentiation
GO:0002297 T-helper 2 cell lineage commitment

Parents of T-helper 2 cell differentiation (GO:0045064)

subject	relation	object
T-helper 2 cell differentiation	RO:0002315	T-helper 2 cell (CL:0000546)
T-helper 2 cell differentiation	is_a	T-helper cell differentiation (GO:0042093)
T-helper 2 cell differentiation	BFO:0000050	type 2 immune response (GO:0042092)

Children of T-helper 2 cell differentiation (GO:0045064)

subject	relation	object
T-helper 2 cell lineage commitment (GO:0002297)	BFO:0000050	T-helper 2 cell differentiation
negative regulation of T-helper 2 cell differentiation (GO:0045629)	RO:0002212	T-helper 2 cell differentiation
regulation of T-helper 2 cell differentiation (GO:0045628)	RO:0002211	T-helper 2 cell differentiation
positive regulation of T-helper 2 cell differentiation (GO:0045630)	RO:0002213	T-helper 2 cell differentiation

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