AmiGO 2: Term Details for "aflatoxin biosynthetic process" (GO:0045122)

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Term Information

Accession: GO:0045122
Name: aflatoxin biosynthetic process
Ontology: biological_process
Synonyms: aflatoxin anabolism, aflatoxin biosynthesis, aflatoxin formation, aflatoxin synthesis
Alternate IDs: None
Definition: The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. Source: ISBN:0716731363, ISBN:0815316194, PMID:15006741
Comment: None
History: See term history for GO:0045122 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to aflatoxin biosynthetic process (excluding "regulates").; Link to all direct and indirect annotations to aflatoxin biosynthetic process (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for aflatoxin biosynthetic process (excluding "regulates").

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GO:0008152 metabolic process
GO:0008150 biological_process
GO:0044237 cellular metabolic process
GO:0071704 organic substance metabolic process
GO:0044281 small molecule metabolic process
GO:0009987 cellular process
GO:0006082 organic acid metabolic process
GO:0009058 biosynthetic process
GO:0043436 oxoacid metabolic process
GO:0019748 secondary metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0044249 cellular biosynthetic process
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0044550 secondary metabolite biosynthetic process
GO:0009404 toxin metabolic process
GO:0032787 monocarboxylic acid metabolic process
GO:0043385 mycotoxin metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:1901376 organic heteropentacyclic compound metabolic process
GO:0009403 toxin biosynthetic process
GO:0006083 acetate metabolic process
GO:0046222 aflatoxin metabolic process
GO:0043386 mycotoxin biosynthetic process
GO:1901378 organic heteropentacyclic compound biosynthetic process
GO:0045122 aflatoxin biosynthetic process
GO:0140399 aflatoxin B synthase activity
GO:0140395 averantin hydroxylase activity
GO:1900178 negative regulation of aflatoxin biosynthetic process
GO:1900179 positive regulation of aflatoxin biosynthetic process
GO:1900177 regulation of aflatoxin biosynthetic process

Parents of aflatoxin biosynthetic process (GO:0045122)

subject	relation	object
aflatoxin biosynthetic process	is_a	organic heteropentacyclic compound biosynthetic process (GO:1901378)
aflatoxin biosynthetic process	RO:0002224	fatty-acyl-CoA synthase activity (GO:0004321)
aflatoxin biosynthetic process	RO:0002230	aflatoxin B synthase activity (GO:0140399)
aflatoxin biosynthetic process	BFO:0000051	versiconal hemiacetal acetate esterase activity (GO:0140397)
aflatoxin biosynthetic process	BFO:0000051	5'-hydroxyaverantin dehydrogenase activity (GO:0140396)
aflatoxin biosynthetic process	BFO:0000051	norsolorinate anthrone synthase activity (GO:0102973)
aflatoxin biosynthetic process	BFO:0000051	sterigmatocystin 7-O-methyltransferase activity (GO:0047146)
aflatoxin biosynthetic process	BFO:0000051	versicolorin B synthase activity (GO:0046572)
aflatoxin biosynthetic process	RO:0004009	acetate (CHEBI:30089)
aflatoxin biosynthetic process	RO:0004008	aflatoxin (CHEBI:22271)
aflatoxin biosynthetic process	BFO:0000051	versicolorin B desaturase activity (GO:0140398)
aflatoxin biosynthetic process	BFO:0000051	versicolorin reductase activity (GO:0042469)
aflatoxin biosynthetic process	BFO:0000051	demethylsterigmatocystin 6-O-methyltransferase activity (GO:0047145)
aflatoxin biosynthetic process	is_a	mycotoxin biosynthetic process (GO:0043386)
aflatoxin biosynthetic process	BFO:0000051	norsolorinic acid ketoreductase activity (GO:0140393)
aflatoxin biosynthetic process	is_a	acetate metabolic process (GO:0006083)
aflatoxin biosynthetic process	BFO:0000051	averantin hydroxylase activity (GO:0140395)
aflatoxin biosynthetic process	is_a	aflatoxin metabolic process (GO:0046222)

Children of aflatoxin biosynthetic process (GO:0045122)

subject	relation	object
negative regulation of aflatoxin biosynthetic process (GO:1900178)	RO:0002212	aflatoxin biosynthetic process
averantin hydroxylase activity (GO:0140395)	BFO:0000050	aflatoxin biosynthetic process
positive regulation of aflatoxin biosynthetic process (GO:1900179)	RO:0002213	aflatoxin biosynthetic process
aflatoxin B synthase activity (GO:0140399)	BFO:0000050	aflatoxin biosynthetic process
regulation of aflatoxin biosynthetic process (GO:1900177)	RO:0002211	aflatoxin biosynthetic process

aflatoxin biosynthetic process