AmiGO 2: Term Details for "alpha-ketoacid dehydrogenase complex" (GO:0045240)

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Term Information

Accession: GO:0045240
Name: alpha-ketoacid dehydrogenase complex
Ontology: cellular_component
Synonyms: 2-oxoacid dehydrogenase complex, dihydrolipoyl dehydrogenase complex
Alternate IDs: None
Definition: A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present. Source: PMID:10745006, GOC:mah
Comment: None
History: See term history for GO:0045240 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to alpha-ketoacid dehydrogenase complex (excluding "regulates").; Link to all direct and indirect annotations to alpha-ketoacid dehydrogenase complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for alpha-ketoacid dehydrogenase complex (excluding "regulates").

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GO:0005575 cellular_component
GO:0003674 molecular_function
PR:000050567 protein-containing material entity
GO:0003824 catalytic activity
GO:0032991 protein-containing complex
GO:1902494 catalytic complex
GO:0016491 oxidoreductase activity
GO:1990204 oxidoreductase complex
GO:0045240 alpha-ketoacid dehydrogenase complex
GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex
GO:0160167 oxoadipate dehydrogenase complex
GO:0045252 oxoglutarate dehydrogenase complex
GO:0045254 pyruvate dehydrogenase complex

Parents of alpha-ketoacid dehydrogenase complex (GO:0045240)

subject	relation	object
alpha-ketoacid dehydrogenase complex	is_a	oxidoreductase complex (GO:1990204)

Children of alpha-ketoacid dehydrogenase complex (GO:0045240)

subject	relation	object
oxoadipate dehydrogenase complex (GO:0160167)	is_a	alpha-ketoacid dehydrogenase complex
oxoglutarate dehydrogenase complex (GO:0045252)	is_a	alpha-ketoacid dehydrogenase complex
pyruvate dehydrogenase complex (GO:0045254)	is_a	alpha-ketoacid dehydrogenase complex
branched-chain alpha-ketoacid dehydrogenase complex (GO:0160157)	is_a	alpha-ketoacid dehydrogenase complex

alpha-ketoacid dehydrogenase complex