AmiGO 2: Term Details for "oxoglutarate dehydrogenase complex" (GO:0045252)

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Term Information

Accession: GO:0045252
Name: oxoglutarate dehydrogenase complex
Ontology: cellular_component
Synonyms: KGDHC, alpha-ketoglutarate dehydrogenase complex, dihydrolipoamide S-succinyltransferase complex
Alternate IDs: None
Definition: A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. Source: PMID:10672230
Comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'oxoglutarate dehydrogenase (NAD+) activity ; GO:0034602'.
History: See term history for GO:0045252 at QuickGO
Chem. react.: None
Subset: goslim_pir
Related: Link to all genes and gene products annotated to oxoglutarate dehydrogenase complex (excluding "regulates").; Link to all direct and indirect annotations to oxoglutarate dehydrogenase complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for oxoglutarate dehydrogenase complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
UBERON:0000061 anatomical structure
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0016491 oxidoreductase activity
GO:0003824 catalytic activity
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0005575 cellular_component
GO:0003674 molecular_function
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors
PR:000050567 protein-containing material entity
GO:1902494 catalytic complex
GO:0005622 intracellular anatomical structure
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0032991 protein-containing complex
GO:0005737 cytoplasm
GO:1990204 oxidoreductase complex
GO:0034601 oxoglutarate dehydrogenase [NAD(P)+] activity
GO:0045240 alpha-ketoacid dehydrogenase complex
GO:0034602 oxoglutarate dehydrogenase (NAD+) activity
GO:0045239 tricarboxylic acid cycle heteromeric enzyme complex
GO:0045252 oxoglutarate dehydrogenase complex

Parents of oxoglutarate dehydrogenase complex (GO:0045252)

subject	relation	object
oxoglutarate dehydrogenase complex	is_a	tricarboxylic acid cycle heteromeric enzyme complex (GO:0045239)
oxoglutarate dehydrogenase complex	is_a	alpha-ketoacid dehydrogenase complex (GO:0045240)
oxoglutarate dehydrogenase complex	RO:0002215	oxoglutarate dehydrogenase (NAD+) activity (GO:0034602)

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Wikipedia: Oxoglutarate_dehydrogenase_complex