AmiGO 2: Term Details for "pyruvate dehydrogenase complex" (GO:0045254)

Term Information

Accession: GO:0045254
Name: pyruvate dehydrogenase complex
Ontology: cellular_component
Synonyms: pyruvate dehydrogenase complex (lipoamide)
Alternate IDs: GO:0009364
Definition: A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. Source: PMID:36863425
Comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (acetyl-transferring) activity ; GO:0004739' (E1), 'dihydrolipoyllysine-residue acetyltransferase activity ; GO:0004742' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'pyruvate dehydrogenase (NAD+) activity ; GO:0034604'.
History: See term history for GO:0045254 at QuickGO
Chem. react.: None
Subset: goslim_pir
Related: Link to all genes and gene products annotated to pyruvate dehydrogenase complex (excluding "regulates").; Link to all direct and indirect annotations to pyruvate dehydrogenase complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for pyruvate dehydrogenase complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0044237 cellular metabolic process
GO:0008152 metabolic process
GO:0008150 biological_process
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:0071704 organic substance metabolic process
GO:0006793 phosphorus metabolic process
GO:0044238 primary metabolic process
GO:0044281 small molecule metabolic process
GO:1901135 carbohydrate derivative metabolic process
GO:0009987 cellular process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0006753 nucleoside phosphate metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:1901576 organic substance biosynthetic process
GO:0019637 organophosphate metabolic process
GO:0006796 phosphate-containing compound metabolic process
GO:0009058 biosynthetic process
GO:1901137 carbohydrate derivative biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:0009117 nucleotide metabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0090407 organophosphate biosynthetic process
GO:0072521 purine-containing compound metabolic process
GO:0019693 ribose phosphate metabolic process
GO:0044249 cellular biosynthetic process
GO:0033865 nucleoside bisphosphate metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0006082 organic acid metabolic process
GO:1901566 organonitrogen compound biosynthetic process
GO:0006163 purine nucleotide metabolic process
GO:0072522 purine-containing compound biosynthetic process
GO:0009259 ribonucleotide metabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0006790 sulfur compound metabolic process
GO:0043603 amide metabolic process
GO:0033866 nucleoside bisphosphate biosynthetic process
GO:0043436 oxoacid metabolic process
GO:0034032 purine nucleoside bisphosphate metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0009150 purine ribonucleotide metabolic process
GO:0033875 ribonucleoside bisphosphate metabolic process
GO:0009260 ribonucleotide biosynthetic process
GO:0044272 sulfur compound biosynthetic process
GO:0035383 thioester metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0043604 amide biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0005575 cellular_component
GO:0003674 molecular_function
GO:0016491 oxidoreductase activity
PR:000050567 protein-containing material entity
GO:0034033 purine nucleoside bisphosphate biosynthetic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0034030 ribonucleoside bisphosphate biosynthetic process
GO:0035384 thioester biosynthetic process
GO:0006084 acetyl-CoA metabolic process
GO:0071616 acyl-CoA biosynthetic process
GO:0003824 catalytic activity
GO:0032787 monocarboxylic acid metabolic process
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0032991 protein-containing complex
GO:0006085 acetyl-CoA biosynthetic process
GO:1902494 catalytic complex
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004738 pyruvate dehydrogenase activity
GO:0006090 pyruvate metabolic process
GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:1990204 oxidoreductase complex
GO:0034603 pyruvate dehydrogenase [NAD(P)+] activity
GO:0045240 alpha-ketoacid dehydrogenase complex
GO:0034604 pyruvate dehydrogenase (NAD+) activity
GO:0045254 pyruvate dehydrogenase complex

Parents of pyruvate dehydrogenase complex (GO:0045254)

subject	relation	object
pyruvate dehydrogenase complex	is_a	alpha-ketoacid dehydrogenase complex (GO:0045240)
pyruvate dehydrogenase complex	RO:0002215	pyruvate dehydrogenase (NAD+) activity (GO:0034604)

This term has no children.

Wikipedia: Pyruvate_dehydrogenase_complex