AmiGO 2: Term Details for "branched-chain alpha-keto acid dehydrogenase activity" (GO:0047101)

Accession: GO:0047101
Name: branched-chain alpha-keto acid dehydrogenase activity
Ontology: molecular_function
Synonyms: 2-oxoisovalerate dehydrogenase activity, 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating), 2-oxoisovalerate dehydrogenase (acylating) activity
Alternate IDs: None
Definition: Catalysis of the reaction: [a branched-chain alpha-keto acid] + CoA + NAD+ = [a branched-chain acyl-CoA] + CO2 + NADH. This enzyme system catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. Source: EC:1.2.1.25, MetaCyc:1.2.1.25-RXN
Comment: None
History: See term history for GO:0047101 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to branched-chain alpha-keto acid dehydrogenase activity (excluding "regulates").; Link to all direct and indirect annotations to branched-chain alpha-keto acid dehydrogenase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for branched-chain alpha-keto acid dehydrogenase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
branched-chain alpha-keto acid dehydrogenase activity	is_a	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620)

subject	relation	object
branched-chain alpha-ketoacid dehydrogenase complex (GO:0160157)	RO:0002215	branched-chain alpha-keto acid dehydrogenase activity