AmiGO 2: Term Details for "RNA polymerase II preinitiation complex assembly" (GO:0051123)

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Term Information

Accession: GO:0051123
Name: RNA polymerase II preinitiation complex assembly
Ontology: biological_process
Synonyms: RNA polymerase II transcription PIC biosynthesis, RNA polymerase II transcription PIC formation, RNA polymerase II transcriptional preinitiation complex assembly, RNA polymerase II transcriptional preinitiation complex formation
Alternate IDs: None
Definition: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA. Source: PMID:15020047, PMID:31300188, GOC:txnOH
Comment: None
History: See term history for GO:0051123 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to RNA polymerase II preinitiation complex assembly (excluding "regulates").; Link to all direct and indirect annotations to RNA polymerase II preinitiation complex assembly (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for RNA polymerase II preinitiation complex assembly (excluding "regulates").

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
GO:0009058 biosynthetic process
GO:0071840 cellular component organization or biogenesis
GO:0044237 cellular metabolic process
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0044238 primary metabolic process
GO:0044249 cellular biosynthetic process
GO:0044085 cellular component biogenesis
GO:0016043 cellular component organization
GO:0009059 macromolecule biosynthetic process
GO:0090304 nucleic acid metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:0022607 cellular component assembly
GO:0010467 gene expression
GO:0141187 nucleic acid biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0043933 protein-containing complex organization
GO:0032774 RNA biosynthetic process
GO:0016070 RNA metabolic process
GO:0006351 DNA-templated transcription
GO:0065003 protein-containing complex assembly
GO:0071824 protein-DNA complex organization
GO:0006352 DNA-templated transcription initiation
GO:0065004 protein-DNA complex assembly
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0070897 transcription preinitiation complex assembly
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0001139 RNA polymerase II complex recruiting activity

Parents of RNA polymerase II preinitiation complex assembly (GO:0051123)

subject	relation	object
RNA polymerase II preinitiation complex assembly	BFO:0000050	transcription initiation at RNA polymerase II promoter (GO:0006367)
RNA polymerase II preinitiation complex assembly	is_a	transcription preinitiation complex assembly (GO:0070897)

Children of RNA polymerase II preinitiation complex assembly (GO:0051123)

subject	relation	object
negative regulation of RNA polymerase II transcription preinitiation complex assembly (GO:0017055)	RO:0002212	RNA polymerase II preinitiation complex assembly
RNA polymerase II complex recruiting activity (GO:0001139)	BFO:0000050	RNA polymerase II preinitiation complex assembly
regulation of RNA polymerase II transcription preinitiation complex assembly (GO:0045898)	RO:0002211	RNA polymerase II preinitiation complex assembly
positive regulation of RNA polymerase II transcription preinitiation complex assembly (GO:0045899)	RO:0002213	RNA polymerase II preinitiation complex assembly

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