AmiGO 2: Term Details for "ubiquitin protein ligase activity" (GO:0061630)

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Term Information

Accession: GO:0061630
Name: ubiquitin protein ligase activity
Ontology: molecular_function
Synonyms: protein ubiquitination activity, ubiquitin ligase activity, ER-associated E3 ligase, E3
Alternate IDs: GO:1904264, GO:0090302, GO:0090622, GO:1904822
Definition: Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. Source: GOC:dph, GOC:tb, GOC:BioGRID, GOC:mah, PMID:22863777
Comment: This enzyme catalyzes a transferase reaction.
History: See term history for GO:0061630 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to ubiquitin protein ligase activity (excluding "regulates").; Link to all direct and indirect annotations to ubiquitin protein ligase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for ubiquitin protein ligase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016755 aminoacyltransferase activity
GO:0140096 catalytic activity, acting on a protein
GO:0019787 ubiquitin-like protein transferase activity
GO:0061659 ubiquitin-like protein ligase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0061630 ubiquitin protein ligase activity
GO:0140852 histone ubiquitin ligase activity
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1904666 regulation of ubiquitin protein ligase activity
GO:0000151 ubiquitin ligase complex
GO:0034450 ubiquitin-ubiquitin ligase activity

Parents of ubiquitin protein ligase activity (GO:0061630)

subject	relation	object
ubiquitin protein ligase activity	is_a	ubiquitin-protein transferase activity (GO:0004842)
ubiquitin protein ligase activity	is_a	ubiquitin-like protein ligase activity (GO:0061659)

Children of ubiquitin protein ligase activity (GO:0061630)

subject	relation	object
negative regulation of ubiquitin protein ligase activity (GO:1904667)	RO:0002212	ubiquitin protein ligase activity
regulation of ubiquitin protein ligase activity (GO:1904666)	RO:0002211	ubiquitin protein ligase activity
ubiquitin-ubiquitin ligase activity (GO:0034450)	is_a	ubiquitin protein ligase activity
positive regulation of ubiquitin protein ligase activity (GO:1904668)	RO:0002213	ubiquitin protein ligase activity
ubiquitin ligase complex (GO:0000151)	RO:0002215	ubiquitin protein ligase activity
histone ubiquitin ligase activity (GO:0140852)	is_a	ubiquitin protein ligase activity

Reactome: R-HSA-6781867; R-HSA-8952419; R-HSA-8866546; R-HSA-5635856; R-HSA-4641159; R-HSA-8953946; R-HSA-8952382; R-HSA-8875183; R-HSA-8939335; R-HSA-8867288; R-HSA-9008076; R-HSA-8877003; R-HSA-5635864; R-HSA-8942101; R-HSA-8956026; R-HSA-4641246; R-HSA-5687081; R-HSA-9759172; R-HSA-6804253; R-HSA-8854051; R-HSA-5682858; R-HSA-8876258; R-HSA-5654677; R-HSA-9766645; R-HSA-8866856; R-HSA-5654679; R-HSA-6790487; R-HSA-9009308; R-HSA-9033485; R-HSA-6782943; R-HSA-9011300; R-HSA-6798373; R-HSA-8854041; R-HSA-9762091; R-HSA-69015; R-HSA-6804724; R-HSA-5654684; R-HSA-8948832; R-HSA-9708517; R-HSA-8851011; R-HSA-6804441; R-HSA-936475; R-HSA-9686969; R-HSA-5690827; R-HSA-8939706; R-HSA-1225956; R-HSA-8938815; R-HSA-9755304; R-HSA-68946; R-HSA-8848829; R-HSA-5632648; R-HSA-8854628; R-HSA-9686920; R-HSA-9755505; R-HSA-9604629; R-HSA-6807106; R-HSA-9759154; R-HSA-5654672; R-HSA-5246693; R-HSA-8956684; R-HSA-6804879; R-HSA-4608852; R-HSA-5684071; R-HSA-1504190; R-HSA-9021523; R-HSA-9009403; R-HSA-9705738; R-HSA-4641129; R-HSA-3322429; R-HSA-5610737; R-HSA-9733316; R-HSA-936462; R-HSA-5689111; R-HSA-183036; R-HSA-9706354; R-HSA-6804942; R-HSA-990526; R-HSA-4641253; R-HSA-6785361; R-HSA-8948775; R-HSA-9706356; R-HSA-9685195; R-HSA-8943003; R-HSA-5674022; R-HSA-5658424; R-HSA-8875431; R-HSA-3640861; R-HSA-6807134; R-HSA-934604; R-HSA-8943080; R-HSA-201445; R-HSA-8938773; R-HSA-8943040