AmiGO 2: Term Details for "shelterin complex" (GO:0070187)

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Term Information

Accession: GO:0070187
Name: shelterin complex
Ontology: cellular_component
Synonyms: Pot1 complex, Pot1-Tpz1 complex, telosome
Alternate IDs: None
Definition: A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1. Source: PMID:18828880, GOC:expert_mf, GOC:vw, GOC:mah
Comment: None
History: See term history for GO:0070187 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to shelterin complex (excluding "regulates").; Link to all direct and indirect annotations to shelterin complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for shelterin complex (excluding "regulates").

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CARO:0030000 biological entity
GO:0008150 biological_process
CARO:0000000 anatomical entity
GO:0009987 cellular process
UBERON:0001062 anatomical entity
GO:0071840 cellular component organization or biogenesis
CARO:0000006 material anatomical entity
GO:0008152 metabolic process
GO:0043226 organelle
GO:0071704 organic substance metabolic process
UBERON:0000061 anatomical structure
GO:0016043 cellular component organization
CARO:0000003 connected anatomical structure
GO:0043229 intracellular organelle
UBERON:0000465 material anatomical entity
GO:0043228 non-membrane-bounded organelle
GO:1901360 organic cyclic compound metabolic process
GO:0044238 primary metabolic process
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0005575 cellular_component
GO:0043232 intracellular non-membrane-bounded organelle
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006996 organelle organization
GO:0005694 chromosome
GO:0051276 chromosome organization
GO:0005622 intracellular anatomical structure
GO:0090304 nucleic acid metabolic process
GO:0098687 chromosomal region
GO:0006259 DNA metabolic process
GO:0043227 membrane-bounded organelle
GO:0032200 telomere organization
GO:0000781 chromosome, telomeric region
GO:0043231 intracellular membrane-bounded organelle
GO:0032991 protein-containing complex
PR:000050567 protein-containing material entity
GO:0000723 telomere maintenance
GO:0140445 chromosome, telomeric repeat region
GO:0005634 nucleus
GO:0032993 protein-DNA complex
GO:0016233 telomere capping
GO:0140513 nuclear protein-containing complex
GO:0000782 telomere cap complex
GO:0000783 nuclear telomere cap complex
GO:0070187 shelterin complex

Parents of shelterin complex (GO:0070187)

subject	relation	object
shelterin complex	is_a	nuclear telomere cap complex (GO:0000783)

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