AmiGO 2: Term Details for "ERK5 cascade" (GO:0070375)

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Term Information

Accession: GO:0070375
Name: ERK5 cascade
Ontology: biological_process
Synonyms: BMK cascade, BMK signaling pathway, BMK signalling pathway, BMK1 cascade, ERK5 signaling pathway, MAPK7 cascade, big MAP kinase signaling cascade, extracellular signal-regulated kinase 5 cascade
Alternate IDs: None
Definition: A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The ERK5 cascade is activated by stress, mitogens, and by G protein-coupled receptors, and results in cellular responses such as cell growth, cell differentiation and development. Source: PMID:20811974, PMID:28903453, PMID:16880823, PMID:23125017, PMID:16376520
Comment: None
History: See term history for GO:0070375 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to ERK5 cascade (excluding "regulates").; Link to all direct and indirect annotations to ERK5 cascade (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for ERK5 cascade (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0000165 MAPK cascade
GO:0070375 ERK5 cascade
GO:0070377 negative regulation of ERK5 cascade
GO:0070378 positive regulation of ERK5 cascade
GO:0070376 regulation of ERK5 cascade

Parents of ERK5 cascade (GO:0070375)

subject	relation	object
ERK5 cascade	is_a	MAPK cascade (GO:0000165)

Children of ERK5 cascade (GO:0070375)

subject	relation	object
negative regulation of ERK5 cascade (GO:0070377)	RO:0002212	ERK5 cascade
positive regulation of ERK5 cascade (GO:0070378)	RO:0002213	ERK5 cascade
regulation of ERK5 cascade (GO:0070376)	RO:0002211	ERK5 cascade

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