AmiGO 2: Term Details for "RISC-loading complex" (GO:0070578)

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Term Information

Accession: GO:0070578
Name: RISC-loading complex
Ontology: cellular_component
Synonyms: miRLC, microRNA loading complex, RLC
Alternate IDs: None
Definition: A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. Source: GOC:rph, PMID:19820710, GOC:BHF, GOC:ab, PMID:18178619, GOC:nc
Comment: None
History: See term history for GO:0070578 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to RISC-loading complex (excluding "regulates").; Link to all direct and indirect annotations to RISC-loading complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for RISC-loading complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0008152 metabolic process
GO:0048519 negative regulation of biological process
GO:0050794 regulation of cellular process
GO:0019222 regulation of metabolic process
GO:0003824 catalytic activity
GO:0044249 cellular biosynthetic process
GO:0043170 macromolecule metabolic process
GO:0048523 negative regulation of cellular process
GO:0009892 negative regulation of metabolic process
GO:0071704 organic substance metabolic process
GO:0009889 regulation of biosynthetic process
GO:0031323 regulation of cellular metabolic process
GO:0071840 cellular component organization or biogenesis
GO:0016787 hydrolase activity
GO:0009059 macromolecule biosynthetic process
GO:0009890 negative regulation of biosynthetic process
GO:0031324 negative regulation of cellular metabolic process
GO:1901576 organic substance biosynthetic process
GO:0031326 regulation of cellular biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0044085 cellular component biogenesis
GO:0016043 cellular component organization
GO:0005575 cellular_component
GO:0010467 gene expression
GO:0016788 hydrolase activity, acting on ester bonds
GO:0003674 molecular_function
GO:0031327 negative regulation of cellular biosynthetic process
GO:0010605 negative regulation of macromolecule metabolic process
PR:000050567 protein-containing material entity
GO:0010556 regulation of macromolecule biosynthetic process
GO:0140098 catalytic activity, acting on RNA
GO:0022607 cellular component assembly
GO:0010558 negative regulation of macromolecule biosynthetic process
GO:0004518 nuclease activity
GO:0032991 protein-containing complex
GO:0043933 protein-containing complex organization
GO:0010468 regulation of gene expression
GO:1902494 catalytic complex
GO:0004519 endonuclease activity
GO:0140535 intracellular protein-containing complex
GO:0010629 negative regulation of gene expression
GO:0065003 protein-containing complex assembly
GO:0071826 protein-RNA complex organization
GO:0022613 ribonucleoprotein complex biogenesis
GO:0004540 RNA nuclease activity
GO:1905348 endonuclease complex
GO:0022618 protein-RNA complex assembly
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0004521 RNA endonuclease activity
GO:1902555 endoribonuclease complex
GO:0070922 RISC complex assembly
GO:0070578 RISC-loading complex

Parents of RISC-loading complex (GO:0070578)

subject	relation	object
RISC-loading complex	RO:0002216	RISC complex assembly (GO:0070922)
RISC-loading complex	RO:0002215	RNA endonuclease activity (GO:0004521)
RISC-loading complex	is_a	endoribonuclease complex (GO:1902555)

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