AmiGO 2: Term Details for "5-methylcytosine dioxygenase activity" (GO:0070579)

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Term Information

Accession: GO:0070579
Name: 5-methylcytosine dioxygenase activity
Ontology: molecular_function
Synonyms: methylcytosine dioxygenase activity
Alternate IDs: None
Definition: Catalysis of the reaction: 5-methylcytosine (5mC) in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine (5hmC) in DNA + succinate + CO2. This reaction is the first step in the removal of cytosine methylated on position 5 in double-stranded DNA. This activity can iteratively oxidize 5hmC to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC). Source: PMID:21778364, PMID:21496894, PMID:19372391
Comment: This reaction removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system. Do not confuse with oxidative DNA demethylase activity ; GO:0035516, which directly reverses the alkylation on nucleodides in the DNA.
History: See term history for GO:0070579 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to 5-methylcytosine dioxygenase activity (excluding "regulates").; Link to all direct and indirect annotations to 5-methylcytosine dioxygenase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for 5-methylcytosine dioxygenase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0051213 dioxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0070579 5-methylcytosine dioxygenase activity

Parents of 5-methylcytosine dioxygenase activity (GO:0070579)

subject	relation	object
5-methylcytosine dioxygenase activity	is_a	2-oxoglutarate-dependent dioxygenase activity (GO:0016706)

This term has no children.

EC: 1.14.11.80
Reactome: R-HSA-9817458; R-HSA-5220990; R-HSA-5221014; R-HSA-5220952
RHEA: 53832; 52636; 53828
WIkipedia: DNA_demethylation