AmiGO 2: Term Details for "interleukin-27 complex" (GO:0070744)

Accession: GO:0070744
Name: interleukin-27 complex
Ontology: cellular_component
Synonyms: IL-27 complex, EBI3, IL27, p28
Alternate IDs: None
Definition: A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space. Source: GOC:add, PMID:15999093, PMID:19161428
Comment: Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits.
History: See term history for GO:0070744 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to interleukin-27 complex (excluding "regulates").; Link to all direct and indirect annotations to interleukin-27 complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for interleukin-27 complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
interleukin-27 complex	is_a	protein-containing complex (GO:0032991)
interleukin-27 complex	BFO:0000050	extracellular space (GO:0005615)

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