AmiGO 2: Term Details for "core mediator complex" (GO:0070847)

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Term Information

Accession: GO:0070847
Name: core mediator complex
Ontology: cellular_component
Synonyms: C mediator complex, S mediator complex
Alternate IDs: None
Definition: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. Source: PMID:16168358, PMID:11454195, PMID:17870225
Comment: None
History: See term history for GO:0070847 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to core mediator complex (excluding "regulates").; Link to all direct and indirect annotations to core mediator complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for core mediator complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0050789 regulation of biological process
CARO:0030000 biological entity
GO:0009058 biosynthetic process
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0044238 primary metabolic process
GO:0050794 regulation of cellular process
GO:0019222 regulation of metabolic process
CARO:0000000 anatomical entity
UBERON:0000061 anatomical structure
GO:0009059 macromolecule biosynthetic process
GO:0090304 nucleic acid metabolic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0080090 regulation of primary metabolic process
UBERON:0001062 anatomical entity
CL:0000000 cell
GO:0110165 cellular anatomical structure
CARO:0000006 material anatomical entity
GO:0141187 nucleic acid biosynthetic process
GO:0043226 organelle
GO:0009889 regulation of biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0019219 regulation of nucleobase-containing compound metabolic process
GO:0016070 RNA metabolic process
CARO:0000003 connected anatomical structure
GO:0010467 gene expression
GO:0005622 intracellular anatomical structure
GO:0043229 intracellular organelle
UBERON:0000465 material anatomical entity
GO:0043228 membraneless organelle
GO:0010556 regulation of macromolecule biosynthetic process
GO:0051252 regulation of RNA metabolic process
GO:0032774 RNA biosynthetic process
GO:0005575 cellular_component
GO:0006351 DNA-templated transcription
GO:0043232 intracellular membraneless organelle
GO:0043227 membrane-bounded organelle
GO:0010468 regulation of gene expression
GO:2001141 regulation of RNA biosynthetic process
GO:0005694 chromosome
GO:0043231 intracellular membrane-bounded organelle
GO:0003674 molecular_function
GO:0006355 regulation of DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0140110 transcription regulator activity
GO:0000785 chromatin
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0032991 protein-containing complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0140513 nuclear protein-containing complex
GO:0005667 transcription regulator complex
GO:0090575 RNA polymerase II transcription regulator complex
GO:0070847 core mediator complex

Parents of core mediator complex (GO:0070847)

subject	relation	object
core mediator complex	is_a	RNA polymerase II transcription regulator complex (GO:0090575)
core mediator complex	RO:0002162	Eukaryota (NCBITaxon:2759)

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