AmiGO 2: Term Details for "medium-chain fatty acyl-CoA dehydrogenase activity" (GO:0070991)

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Term Information

Accession: GO:0070991
Name: medium-chain fatty acyl-CoA dehydrogenase activity
Ontology: molecular_function
Synonyms: MCAD activity
Alternate IDs: None
Definition: Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. Source: RHEA:14477
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
History: See term history for GO:0070991 at QuickGO
Chem. react.: has participant hydron; has participant medium-chain 3-substituted propanoyl-CoA(4-); has participant medium-chain 2,3-trans-enoyl CoA(4-); has participant FAD(3-); has participant FADH2(2-)
Subset: None
Related: Link to all genes and gene products annotated to medium-chain fatty acyl-CoA dehydrogenase activity (excluding "regulates").; Link to all direct and indirect annotations to medium-chain fatty acyl-CoA dehydrogenase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for medium-chain fatty acyl-CoA dehydrogenase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
GO:0003995 acyl-CoA dehydrogenase activity
GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity

Parents of medium-chain fatty acyl-CoA dehydrogenase activity (GO:0070991)

subject	relation	object
medium-chain fatty acyl-CoA dehydrogenase activity	RO:0000057	hydron (CHEBI:15378)
medium-chain fatty acyl-CoA dehydrogenase activity	RO:0000057	medium-chain 3-substituted propanoyl-CoA(4-) (CHEBI:83723)
medium-chain fatty acyl-CoA dehydrogenase activity	RO:0000057	medium-chain 2,3-trans-enoyl CoA(4-) (CHEBI:83726)
medium-chain fatty acyl-CoA dehydrogenase activity	RO:0000057	FAD(3-) (CHEBI:57692)
medium-chain fatty acyl-CoA dehydrogenase activity	is_a	acyl-CoA dehydrogenase activity (GO:0003995)
medium-chain fatty acyl-CoA dehydrogenase activity	RO:0000057	FADH2(2-) (CHEBI:58307)

This term has no children.

EC: 1.3.8.7
RHEA: 14477