AmiGO 2: Term Details for "heteromeric SMAD protein complex" (GO:0071144)

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Term Information

Accession: GO:0071144
Name: heteromeric SMAD protein complex
Ontology: cellular_component
Synonyms: SMAD1-SMAD4 protein complex, SMAD2-SMAD3-SMAD4 protein complex, SMAD2-SMAD4 protein complex, SMAD3-SMAD4 protein complex
Alternate IDs: GO:0071145, GO:0071146
Definition: A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric. Source: PMID:9389648, PMID:15350224, PMID:11779505, GOC:mah, PMID:9670020, PMID:16322555, GOC:bhm
Comment: None
History: See term history for GO:0071144 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to heteromeric SMAD protein complex (excluding "regulates").; Link to all direct and indirect annotations to heteromeric SMAD protein complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for heteromeric SMAD protein complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
GO:0008150 biological_process
UBERON:0001062 anatomical entity
GO:0065007 biological regulation
GO:0009987 cellular process
CARO:0000006 material anatomical entity
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
GO:0050789 regulation of biological process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
CARO:0000003 connected anatomical structure
GO:0043170 macromolecule metabolic process
UBERON:0000465 material anatomical entity
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0044238 primary metabolic process
GO:0050794 regulation of cellular process
GO:0019222 regulation of metabolic process
UBERON:0000061 anatomical structure
GO:0044249 cellular biosynthetic process
GO:0005575 cellular_component
GO:0090304 nucleic acid metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:0009889 regulation of biosynthetic process
GO:0031323 regulation of cellular metabolic process
GO:0080090 regulation of primary metabolic process
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0009059 macromolecule biosynthetic process
GO:0141187 nucleic acid biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0043226 organelle
GO:0031326 regulation of cellular biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0019219 regulation of nucleobase-containing compound metabolic process
GO:0016070 RNA metabolic process
GO:0010467 gene expression
GO:0005622 intracellular anatomical structure
GO:0043229 intracellular organelle
GO:0043228 non-membrane-bounded organelle
GO:0010556 regulation of macromolecule biosynthetic process
GO:0051252 regulation of RNA metabolic process
GO:0032774 RNA biosynthetic process
GO:0006351 DNA-templated transcription
GO:0043232 intracellular non-membrane-bounded organelle
GO:0043227 membrane-bounded organelle
GO:0032991 protein-containing complex
GO:0010468 regulation of gene expression
GO:2001141 regulation of RNA biosynthetic process
GO:0005694 chromosome
GO:0043231 intracellular membrane-bounded organelle
GO:0003674 molecular_function
GO:0032993 protein-DNA complex
GO:0006355 regulation of DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0140110 transcription regulator activity
GO:0000785 chromatin
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
PR:000050567 protein-containing material entity
GO:0006357 regulation of transcription by RNA polymerase II
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0140513 nuclear protein-containing complex
GO:0005667 transcription regulator complex
GO:0090575 RNA polymerase II transcription regulator complex
GO:0071141 SMAD protein complex
GO:0071144 heteromeric SMAD protein complex

Parents of heteromeric SMAD protein complex (GO:0071144)

subject	relation	object
heteromeric SMAD protein complex	is_a	SMAD protein complex (GO:0071141)
heteromeric SMAD protein complex	is_a	RNA polymerase II transcription regulator complex (GO:0090575)

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