AmiGO 2: Term Details for "histone H3K27me2/H3K27me3 demethylase activity" (GO:0071558)

Accession: GO:0071558
Name: histone H3K27me2/H3K27me3 demethylase activity
Ontology: molecular_function
Synonyms: histone H3-tri/di-methyl-lysine-27 demethylase activity, histone H3K27me2 demethylase activity, histone H3K27me3 demethylase activity, histone demethylase activity (H3-K27 specific)
Alternate IDs: None
Definition: Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. Source: GOC:sp, PMID:20622853
Comment: None
History: See term history for GO:0071558 at QuickGO
Chem. react.: has participant succinate(2-); has participant formaldehyde; has participant N(6),N(6),N(6)-trimethyl-L-lysine residue; has participant dioxygen; has participant N(6)-methyl-L-lysinium residue; has participant carbon dioxide; has participant 2-oxoglutarate(2-)
Subset: None
Related: Link to all genes and gene products annotated to histone H3K27me2/H3K27me3 demethylase activity (excluding "regulates").; Link to all direct and indirect annotations to histone H3K27me2/H3K27me3 demethylase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for histone H3K27me2/H3K27me3 demethylase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
histone H3K27me2/H3K27me3 demethylase activity	RO:0000057	succinate(2-) (CHEBI:30031)
histone H3K27me2/H3K27me3 demethylase activity	RO:0000057	formaldehyde (CHEBI:16842)
histone H3K27me2/H3K27me3 demethylase activity	RO:0000057	N(6),N(6),N(6)-trimethyl-L-lysine residue (CHEBI:61961)
histone H3K27me2/H3K27me3 demethylase activity	RO:0000057	dioxygen (CHEBI:15379)
histone H3K27me2/H3K27me3 demethylase activity	is_a	histone H3 demethylase activity (GO:0141052)
histone H3K27me2/H3K27me3 demethylase activity	RO:0000057	N(6)-methyl-L-lysinium residue (CHEBI:61929)
histone H3K27me2/H3K27me3 demethylase activity	is_a	2-oxoglutarate-dependent dioxygenase activity (GO:0016706)
histone H3K27me2/H3K27me3 demethylase activity	RO:0000057	carbon dioxide (CHEBI:16526)
histone H3K27me2/H3K27me3 demethylase activity	RO:0000057	2-oxoglutarate(2-) (CHEBI:16810)

This term has no children.

EC: 1.14.11.68
Reactome: R-HSA-3222593; R-HSA-5617887; R-HSA-9822985; R-HSA-5617431; R-HSA-9822914
RHEA: 60224