AmiGO 2: Term Details for "EMC complex" (GO:0072546)

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Term Information

Accession: GO:0072546
Name: EMC complex
Ontology: cellular_component
Synonyms: ER membrane protein complex, endoplasmic reticulum membrane protein complex
Alternate IDs: None
Definition: A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. Source: PMID:30415835, PMID:29242231, PMID:32459176
Comment: Note that this complex used to be thought to be involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane, but newer findings show that this was incorrect.
History: See term history for GO:0072546 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to EMC complex (excluding "regulates").; Link to all direct and indirect annotations to EMC complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for EMC complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
UBERON:0000061 anatomical structure
CL:0000000 cell
GO:0110165 cellular anatomical entity
CARO:0000003 connected anatomical structure
GO:0005622 intracellular anatomical structure
UBERON:0000465 material anatomical entity
GO:0043226 organelle
GO:0005575 cellular_component
GO:0043229 intracellular organelle
GO:0043227 membrane-bounded organelle
GO:0005737 cytoplasm
GO:0012505 endomembrane system
GO:0005783 endoplasmic reticulum
GO:0043231 intracellular membrane-bounded organelle
GO:0016020 membrane
GO:0031984 organelle subcompartment
PR:000050567 protein-containing material entity
GO:0098827 endoplasmic reticulum subcompartment
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network
GO:0031090 organelle membrane
GO:0032991 protein-containing complex
GO:0005789 endoplasmic reticulum membrane
GO:0140534 endoplasmic reticulum protein-containing complex
GO:0098796 membrane protein complex
GO:0072546 EMC complex

Parents of EMC complex (GO:0072546)

subject	relation	object
EMC complex	is_a	membrane protein complex (GO:0098796)
EMC complex	is_a	endoplasmic reticulum protein-containing complex (GO:0140534)
EMC complex	BFO:0000050	endoplasmic reticulum membrane (GO:0005789)

This term has no children.