Term Information

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Accession
GO:0072559
Name
NLRP3 inflammasome complex
Ontology
cellular_component
Synonyms
NALP3 inflammasome complex
Alternate IDs
None
Definition
An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. Source: PMID:20303873, GOC:BHF, GOC:add, GOC:vp
Comment
None
History
See term history for GO:0072559 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of NLRP3 inflammasome complex (GO:0072559)
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NLRP3 inflammasome complex [is_a relation] is_a  canonical inflammasome complex (GO:0061702)

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