AmiGO 2: Term Details for "box H/ACA RNP complex" (GO:0072588)

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Term Information

Accession: GO:0072588
Name: box H/ACA RNP complex
Ontology: cellular_component
Synonyms: box H/ACA snoRNP pseudouridylase complex, sRNP complex
Alternate IDs: None
Definition: A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex. Source: GOC:BHF_telomerase, PMID:20227365, GOC:krc, PMID:17284456, GOC:jbu, GOC:BHF, GOC:vw, PMID:25590339, GOC:mah
Comment: None
History: See term history for GO:0072588 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to box H/ACA RNP complex (excluding "regulates").; Link to all direct and indirect annotations to box H/ACA RNP complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for box H/ACA RNP complex (excluding "regulates").

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Additional internal viewing options

GO:0005575 cellular_component
PR:000050567 protein-containing material entity
GO:0032991 protein-containing complex
GO:1990904 ribonucleoprotein complex
GO:0005732 sno(s)RNA-containing ribonucleoprotein complex
GO:0072588 box H/ACA RNP complex
GO:0072589 box H/ACA scaRNP complex
GO:0031429 box H/ACA snoRNP complex
GO:0090661 box H/ACA telomerase RNP complex

Parents of box H/ACA RNP complex (GO:0072588)

subject	relation	object
box H/ACA RNP complex	is_a	sno(s)RNA-containing ribonucleoprotein complex (GO:0005732)

Children of box H/ACA RNP complex (GO:0072588)

subject	relation	object
box H/ACA telomerase RNP complex (GO:0090661)	is_a	box H/ACA RNP complex
box H/ACA scaRNP complex (GO:0072589)	is_a	box H/ACA RNP complex
box H/ACA snoRNP complex (GO:0031429)	is_a	box H/ACA RNP complex

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